synthesis and cytotoxicity assessment of gold-coated magnetic iron oxide nanoparticles
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abstract
introduction: one class of magnetic nanoparticles is magnetic iron oxide nanoparticles (mions) which has been widely offered because of their many advantages. because of extensive application of mions in biomedicine, before they can be used in vivo, their cytotoxicity must be investigated. therefore, there is an urgent need for understanding the potential risks associated with mions. materials and methods: firstly, gold-coated fe3o4 nanoparticles (gmnp) were synthesized. the size, structure and spectroscopic properties of the nanoparticles characterized by transmission electron microscopy (tem), x-ray diffractometry (xrd) and uv-visible spectrophotometer, respectively. cytotoxicity of nanoparticles was studied with different concentrations ranging from 10 µg/ml up to 400 µg/ml and for different incubation times (12 h and 24 h) on mcf-7 and hfff-pi6. cytotoxicity study was performed by mtt assay. results: xrd pattern confirmed the structure of gmnps and tem image shows that gmnps are under 50 nm. for mcf-7 and hfff-pi6 cells, at concentration of 300 and 400 µg/ml, fe3o4 nanoparticles are toxic, respectively. moreover, for both cells, cell viability for gmnps is higher than %80, therefore, up to 400 µg/ml they are not toxic. results show that for both cells, fe3o4 nanoparticles have higher cytotoxicity than gmnps. conclusion: this finding suggests that gold coating reduces the toxic effects of uncoated fe3o4 nanoparticles. less toxicity of gmnp may be attributed to controlled release of fe2+ ions in intracellular space. moreover, cell toxicity increased with increase in dose (concentration) and incubation time. normal 0 false false false en-us x-none ar-sa
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Journal title:
journal of biomedical physics and engineeringجلد ۲۰۱۲، شماره ۱۲، صفحات ۰-۰
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